moocStructural Biochemistry期末答案(慕课2023完整答案)
Quiz 1
1、期末The答案答案 proteinogenic amino acid is
A、Gamma-GABA
B、慕课Citriline
C、完整Hydroxyproline
D、期末Pyrrolysine
E、答案答案Cystine
2、慕课The完整 amino acid without optical activity is
A、Cysteine
B、期末Lysine
C、答案答案Glysine
D、慕课Alanine
E、完整Leucine
3、期末The答案答案 amino acid which can be phosphorylated is
A、Alanine
B、慕课Serine
C、Leucine
D、Proline
E、Asparagine
4、The amino acid with three pKa is
A、Alanine
B、Asparagine
C、Cysteine
D、Glutamine
E、Proline
5、If the pKa's of amino, thiol and carboxyl groups of cysteine are 11, 8 and 2 respectively, then its pI will be
A、9.5
B、5
C、6.5
D、7
6、The amino acid which exists in the trans-membrance alpha-helix most possibly is
A、Leucine
B、Arginine
C、Aspartic acid
D、Proline
E、Threnine
7、The amino acid which cannot react with nitrite is
A、Glysine
B、Proline
C、Lysine
D、Leucine
E、Valine
8、The chemical bond stabilizing the secondary structure of proteins is primarily
A、peptide bond
B、hydrogen bond
C、hydrophobic interaction
D、Van der Waals forces
E、Ionic bond
9、The major force driving the folding of proteins is
A、Hydrogen bond
B、Hydrophobic interaction
C、Disulfide bond
D、Ionic bond
E、Van der Waals forces
10、The method that can be used to sequence the proteins is
A、MS
B、X-ray cystallography
C、NMR
D、Cyro-EM
11、Polylysine at pH 2 can form
A、alpha-helix
B、beta-sheet
C、beta-turn
D、beta-bulge
E、random coil
12、Intracellular proteins usually lack
A、hydrophobic interaction
B、ionic bond
C、disulfide bond
D、van de walls foreces
E、hydrogen bond
13、Assume the peptide whose sequence is ACDEFGHILMN folds into a stable alpha-helx, the residue that forms a hydrogen bond with amino N of F in this helix is
A、A
B、C
C、I
D、L
E、E
14、Collagens don't form beta-sheet just because they are rich in
A、Glysine
B、Proline
C、Lysine
D、Alanine
15、One molecule of Hb can bind at most
A、one molecule of oxygen
B、two molecule of oxygen
C、three molecule of oxygen
D、four molecule of oxygen
16、The protein having the quaternary structure is
A、insulin
B、immunoglobulin
C、myoglobin
D、lactate dehydrogenase
E、ribonuclease A
17、If you go from low altitude to high altitude, the 2,3-BPG level will
A、increase
B、decrease
C、not change
D、be unpredicted
18、The binding of HbA with 2,3-BPG mainly depends on
A、hydrophobic interaction
B、ionic bond
C、hydrogen bond
D、van der walls forces
19、The 2,3-BPG binding site of HbA are rich in
A、acidic residues
B、basic residues
C、hydrophobic residues
D、aromatic residues
E、neutral residues
20、The condition of increasing the affinity of Hb with O2 is
A、a increase in CO2
B、a increase in 2,3-BPG
C、a increase in pH
D、a increase in temperature
21、Amino acid that can form ionic bond with its side chain group and lysine side chain group is
A、His
B、Arg
C、Asp
D、Leu
E、Gln
22、Which mutation is most likely to cause the protein to lose its biological activity?
A、S?T
B、N?Q
C、R?K
D、H?V
E、L?V
23、The function of the EF-hand is to bind
A、Calcium ion
B、Magnesium ion
C、Sodium ion
D、Potassium ion
24、The amino acids that can serve as neurotransmitters include
A、Asp
B、Asn
C、Glu
D、Gly
E、Gln
25、Amino acids having three pKa's include
A、C
B、K
C、Q
D、Y
E、H
26、The essential amino acids include
A、K
B、I
C、F
D、Y
E、M
27、The hydrophobic amino acids include
A、A
B、L
C、R
D、Y
E、V
28、Residues which tend to be located on the surface of the proteins include
A、Ser
B、Cys
C、Lys
D、Val
E、Asp
29、The chemical bonds stabilizing the 3-D structure of hemoglobin include
A、hydrogen bond
B、hydrophobic interaction
C、ionic bond
D、van der Walls foreces
E、disulfide bond
30、The chaperones involved in protein folding include
A、HSP60
B、HSP10
C、HSP70
D、PDI
E、PPI
31、The amino acid residues which can be recongnized and combined by HSP70 include
A、K
B、I
C、L
D、D
E、V
32、Proline hydroxylation in collagen requires
A、vitamine C
B、O2
C、hydroxylase
D、alpha-ketoglutarate
E、ferric ion
33、The ligands whic can bind to HbA include
A、O2
B、CO2
C、CO
D、2,3-BPG
E、NO
34、The methods that can be used to determine the 3-D structure of proteins include
A、X-ray diffraction
B、NMR
C、MS
D、Cyo-EM
E、Edman degradation
35、All peptide bonds directly introduced into the proteins during translation exist in trans.
36、Proline cannot react with DNFB.
37、D-Ala and L-Ala have the same molecular weight, same melting point and same water-solubility.
38、Our human bodies contain 22 proteinogenic amino acids including pyrrolysine.
39、The peptide bond in the middle of the Pro-X (X represents other amino acids) sequence can be cis.
40、All proteins have the primary structure, secondary structure and tertiary structure.
41、The ninhydrin reaction is unique to amino acids, by which we can distinguish amino acids from peptides.
42、All peptides are synthesized on the ribosomes
43、Hydrophobic amino acids are water-insoluble.
44、Alpha-keratin, insulin and immunoglobulin all contain disulfide bonds.
45、The direction of optical rotation of L-amino acid must be left-handed.
46、The alpha-helix composed of D-amino acids is usually left-handed
47、The sequence AGPP in the polypetide can form a beta-turn.
48、Proline is never found to exist in the alpha-helix.
49、A lof of energies are released during the protein folding.
50、Protein folding is an energetically favorable process.
Chapter 2 Structure and Function of Nucleic Acids
Quiz 2
1、The fifth base of DNA is
A、U
B、I
C、X
D、5-methylated C
2、The RNA double helix belongs to
A、A type
B、B type
C、C type
D、Z type
3、If a codon is AUG, its corresponding anticodon will be
A、UAC
B、CAU
C、TAC
D、CAT
4、The purine ring atom linking ribosoe in the nucleosides or nucleotides is
A、N1
B、N3
C、N7
D、N9
5、The pyrimidine atom in the pseudouridine linking ribose is
A、N1
B、C2
C、N3
D、C4
E、C5
6、The nucleotide called the universal energy currency is just
A、ATP
B、GTP
C、CTP
D、UTP
7、The RNA containing T is
A、tRNA
B、mRNA
C、rRNA
D、snRNA
E、7SL RNA
8、The biological macromolecule that first appeared during the evolution of life is
A、DNA
B、RNA
C、Protein
D、monosaccharide
9、The last three base sequence of tRNA is
A、ACC
B、CCA
C、CAA
D、ACA
10、The base sequence that most favors the formation of Z-type DNA double helix under the same condition is
A、GGGGGGGGGG
B、CGCGCGCGCG
C、ATATATATAT
D、AAAAAAAAAA
11、The bases containing amino group include
A、C
B、A
C、T
D、G
E、U
12、The base pairs in the RNA double helix include
A、A-T
B、A-U
C、G-C
D、G-U
E、A-C
13、The nucleotides that can act as second messenger during sigal transduction
A、2',3'-cAMP
B、2',3'-cGMP
C、3',5'-cAMP
D、3',5'-cGMP
14、The RNAs unique to Eukaryotes include
A、7SL RNA
B、miRNA
C、SnRNA
D、crRNA
E、Xist RNA
15、The RNA-Protein complex include
A、nucleosome
B、ribonuclease P
C、telomerase
D、ribosome
E、SRP
16、The RNA viruses include
A、HAV
B、HBV
C、HIV
D、HPV
E、SARS-COV-2
17、The common properties that A-DNA, B-DNA and Z-DNA include
A、right-handed
B、antiparallel
C、the same base-pairing rules
D、double-stranded
E、highly negatively charged
18、The RNA-DNA double helix can form during
A、DNA replication
B、DNA transcription
C、revere transcription
D、RNA replication
E、PCR
19、The RNAs the all living organism have include
A、tRNA
B、rRNA
C、mRNA
D、SRP-RNA
E、snRNA
20、The secondary structures which can occur in the living cells include
A、A-type double helix
B、B-type doublce helix
C、Z-type double helix
D、Triplex helix
E、C-type double helix
21、The nucleic acid containing T must be DNA.
22、The glycosylic bond in the naturally-occurring ribonucleotides must be beta-type.
23、Bases, nucleosides and nucleotides all have the UV absorption property.
24、Only eukaryotes contain nucleosomes.
25、If DNA molecules used U instead of T, mutations would occur more easily.
26、Single-stranded RNA or DNA cannot form double helix structure.
27、The naturally-occurring nucleotides are usually 5'-nucleotides.
28、Some naturally-occurring DNAs have be found to contain U instead of T.
29、If the sequence of one strand of DNA is GATACT, the sequence of other strand of this DNA will be CTATGA.
30、The pseudo-knot is a kind of secondary structure of RNA.
31、RNA folding usually requires metal ions.
Chapter 3 Properties of Proteins and Nucleic Acids
Quiz 3
1、The salt commonly used for salting out proteins is
A、NaCl
B、KCl
C、Cacium chloride
D、Ammonium sulphate
E、Sodium sulphate
2、The common feature of protein denaturation and DNA denaturation is
A、loss of function
B、change of configuration
C、breaking of covalent bonds
D、breaking of hydrogen bonds
E、the decrease of viscocity
3、After the tripeptide DNA is completely hydrolyzed under acidic conditions, the resulting amino acids products will be
A、D+N+A
B、2D+A
C、D+A
D、A
E、D
4、There are three different types of double-stranded DNA molecules: molecule 1 is 1 000 bp and the GC content is 50%; molecule 2 is 1 000 bp and the GC content is 70%; molecule 3 is 2 000 bp and the GC content is 40%. If they are subjected to thermal denaturation experiments under the same conditions, the expected result is:
A、Molecule 1 has the highest Tm
B、Molecule 2 has the highest Tm
C、Molecule 3 has the highest Tm
D、Molecules 1 and 2 have higher Tm than Molecule 3
E、The three molecules have the same Tm
5、If chymotrypsin is used to completely hydrolyze the polypeptide GGFEEWREAKGSYVV, the number of the resulting small peptides with ultraviolet absorption is:
A、1
B、2
C、3
D、4
E、5
6、PCR primers for isolation and purification should use:
A、Polyacrylamide gel electrophoresis
B、Agarose gel electrophoresis
C、Paper electrophoresis
D、Isoelectric focusing electrophoresis
E、SDS-PAGE
7、Resins containing covalently coupled ADP are often used to purify proteins:
A、dehydrogenases
B、globin
C、collagen
D、cytochrome
E、transaminase
8、The below proteins are separated by PAGE under the conditions of SDS and without SDS, the proteins with varying number of bands include
A、insulin
B、antibody
C、HbA
D、Mb
E、lactate dehyrogenase
9、The breaking chemical bonds during protein denaturation include
A、hydrogen bond
B、peptide bond
C、disulfide bond
D、ionic bond
E、hydrophobic interactionb
10、Indicators of DNA degeneration include:
A、hyperochromic effect
B、loss of function
C、decrease viscocity
D、increased buoyant density
E、unwinding
11、The factors that can cause the denaturation of both protein and DNA are:
A、heating
B、urea
C、SDS
D、UV
E、strong acid
12、The peptide bonds recognized by chymotrypsin are (X represents amino acids other than F, Y and W):
A、W-X
B、X-W
C、Y-X
D、X-Y
E、F-X
13、Biomolecules with amphoteric dissociative properties are:
A、amino acids
B、proteins
C、nucleotides
D、RNA
E、DNA
14、If a peptide is hydrolyzed under alkaline conditions and D-amino acid products are found, this indicates that the polypeptide originally contained D-amino acids
15、DNA are easily denatred under ether strong acid or extreme alkaline condition.
16、Ultraviolet light and X-rays can easily cause denaturation of proteins or DNA.
17、The density of RNA is higher than that of DNA.
18、Once denatured, the DNA will lose its biological function.
19、DNA with high GC content must have a higher Tm than DNA with high AT content
20、The molecular weight cannot change when proteins and nucleic acids are denatured.
Chapter 4 Structure and Function of Enzymes
Quiz4
1、The main reasons why DNA cannot be used as an enzyme are:
A、Cannot form a single stranded structure
B、Contains T
C、Contains no U
D、Lack 2'-OH
E、Cannot bind metal ions
2、The virus that belongs to ribozymes is:
A、HAV
B、HBV
C、HCV
D、HDV
E、HIV
3、The following amino acid residues that are most unlikely to participate in the catalytic reaction at the enzyme active center are:
A、Ala
B、Ser
C、Cys
D、Tyr
E、Lys
4、The aldolase involved in glycolysis belongs to:
A、EC1
B、EC2
C、EC3
D、EC4
E、EC5
F、EC6
5、If an enzyme uses kinetics as a means of regulation, then the enzyme substrate concentration is usually found to be:
A、close to Km
B、Far below the Km
C、Far above the Km
D、close to kcat/Km
E、[E]
6、Do you think the common properties of alcohol dehydrogenase in mice and humans must be:
A、optimal pH
B、optimal temperature
C、kcat
D、Km
E、the equilibirum constant
7、After a typical Michaelis enzyme doubles its concentration, the Km value will:
A、increase by two times
B、double
C、decrease by two times
D、halve
E、stay the same
8、The double reciprocal plot of an enzyme shows a slope of 5×10-4min/L and a longitudinal intercept of 0.1min/mol. From which you can conclude that:
A、Km/Vmax is 200
B、The turnover number of the enzyme is 100min-1
C、The equilibrium constan of which the enzyme substrate complex dissociates into tenzyme and product is 0.005mol/L
D、When the substrate concentration is 0.005mol/L, the reaction rate is 5mol/min
E、The reaction rate increases linearly with increasing substrate concentration
9、Which inhibition can be reduced by increasing the [S] is:
A、competitive inhibition
B、non-competitive inhibition
C、uncompetitive inhibition
D、irreversible inhibition
E、unpredictable
10、When the degree of inhibition is 50%, [I]=Ki. The inhibitor belongs to:
A、competitive inhibition
B、non-competitive inhibition
C、uncompetitive inhibition
D、irreversible inhibition
E、unpredictable
11、Uncompetitive inhibitors of enzymes can:
A、decrease both Vmax and Km
B、increase both Vmax and Km
C、don't change Vmax, but increase Km
D、don't change Vmax, but decrease Km
E、decrease Vmax and increase Km
12、Diisopropylfluorophosphoric acid and iodoacetic acid are enzyme group-specific inhibitors and are specific for two amino acid residues, these two amino acid residues are respectively:
A、Thr and Ser
B、Thr and Cys
C、Ser and His
D、Ser and Cys
E、Cys and Ser
13、Assuming that a mutation causes the structure of the active center of an enzyme to be more complementary to the substrate than to the transition state, the effect of this mutation on the enzymatic reaction is:
A、Increasing the reaction rate
B、decreasing the reaction rate
C、unchanging the reaction rate
D、changing the equilibrium constant
E、being unpredictable
14、Among the various regulatory mechanisms of enzyme activity, the slowest one is:
A、enzyme synthesis
B、enzyme degradtion
C、allosteric control
D、proteolytic activation
E、covalent modification
15、The following defects that have the most serious impact on protein digestion come from:
A、chymotrypsin
B、trypsin
C、pepsin
D、elastase
E、carboxylpeptidase
16、The vitamin that the gastrectomy patients and vegans are prone to lack is:
A、B1
B、B2
C、B3
D、B6
E、B12
17、Vitamin that are easily deficient in blocked biliary tract is
A、A
B、C
C、B1
D、B2
E、B3
18、The vitamin whose deficiency can cause beriberi is
A、B1
B、B2
C、B3
D、B5
E、B6
19、The vitamin associated with coenzyme I is
A、B1
B、B2
C、B3
D、B6
E、B12
20、The model used to explain the stereospecificity of enzyme action is
A、lock and key
B、induced fit
C、three-point attachment
D、the concerted change
E、the sequential change
21、The following statements about enzymes are correct:
A、all requries cofactors
B、Catalyzes both forward and reverse reactions
C、Does not change the equilibrium constant
D、Can be denatured
E、The chemical nature can be either protein or RNA
22、Among the following descriptions of ribozymes, the correct ones are:
A、Must be an enzyme catalyzed by RNA
B、RNA-containing enzymes are not necessarily ribozymes
C、Ribosome is essentially a ribozyme
D、The kinetics of ribozymes usually follows the Michaelis equation
E、Most ribozymes require metal ions as cofactors
23、Ribozymes include:
A、ribosome
B、spliceosome
C、RNase P
D、HDV
E、some viroids
24、The interactions between proteins and ligands, which are manifested as the induced-fit process, are:
A、binding of antibody and antigen
B、The combination of virtual iron stickase and its iron stick substrate
C、Combination of hexokinase and glucose
D、The combination of hemoglobin and oxygen
E、Combination of citrate synthase with oxaloacetate and acetyl-CoA
25、Inhibitors suitable for medicine are:
A、competitive inhibitors
B、transitation state analougues
C、group-specific inhibitors
D、 inhibitors
E、substrate analouges
26、The following false statements about allosteric enzymes are:
A、Always oligomerase
B、Always combine with allosteric effectors by non-covalent bonds
C、The kinetic curve of the reaction is always sigmoidal
D、The presence of negative allosteric effectors of allosteric enzymes can enhance their positive cooperativity
E、in the majority in cells
27、The groups which can participate in general acid catalysis include:
A、-OH
B、-SH
C、-COO-
D、-NH3+
E、-SeH
28、In the active site of the enzyme, the amino acids whose side chain groups can participate in the catalysis are:
A、S
B、Y
C、C
D、K
E、D
29、Amino acid residues that can undergo phosphorylation modification include:
A、S
B、T
C、Y
D、H
E、D
F、N
30、The catalytic mechanisms used by lysozyme include:
A、general acid catalysis
B、general base catalysis
C、Electrostatic catalysis
D、covalent catalysis
E、substrate strain
31、The important physiological or biochemical processes involved in proteases include:
A、Food digestion
B、apoptosis
C、blood clotting
D、Eukaryotic cell cycle regulation
E、regulation of enzyme activity
32、The fat-soluble vitamins are:
A、A
B、C
C、D
D、E
E、K
33、The amino acid residues that constitute the catalytic triad of serine proteases are:
A、H
B、C
C、D
D、S
E、K
34、Deoxyribozymes have been found in living organisms, and its chemical nature is DNA.
35、All enzymes catalyze both forward and reverse reactions.
36、Some reactions in cells are irreversible, because the relevant enzymes only catalyze the forward reactions.
37、The side chain of a hydrophobic amino acid cannot catalyze the reaction in the active site of the enzyme
38、Allosteric enzymes must have a quaternary structure
39、Ribosomes are essentially a ribozyme, which catalyzes the reaction of all steps of protein synthesis.
40、The process of phosphorylation of enzymes is reversible, because the reaction catalyzed by protein kinases in cells is reversible
41、The irreversible inhibitor of the enzyme must be bound to the enzyme through a covalent bond
42、Uncompetitive inhibitors of enzymes alone cannot bind to enzymes
43、The presence of allosteric inhibitors can enhance the positive cooperativity of allosteric enzymes
44、Mice don’t get scurvy because they can synthesize vitamin C by themselves
45、Allosteric effectors bind to allosteric enzymes always by non-covalent bonds
46、Vitamin K is also called anticoagulant vitamin
47、Enzymes that use ATP as a substrate or product generally require magnesium ions
48、The human body can synthesize vitamins by itself
Chapter 5 Structure and Function of Carbohydrates and Lipids
Quiz5
1、The concentration of glucose solution that is the most difficult for bacteria to survive is:
A、5%
B、10%
C、20%
D、30%
E、50%
2、The carbon atom that determines whether glucose is a D or L stereoisomer is:
A、C1
B、C2
C、C3
D、C4
E、C5
3、The carbon atom that determines whether glucose is an alpha or beta anomer is:
A、C1
B、C2
C、C3
D、C4
E、C5
4、The number of stereoisomers of hexanal aldose in the ring structure is:
A、2
B、4
C、8
D、16
E、32
5、The pair of monosaccharides belonging to the epimer are:
A、D-ribose and D-ribulose
B、D-glucose and D-mannose
C、D-glucose and D-fructose
D、D-mannose and D-galactose
E、D-arabinose and D-xylose
6、The free fatty acid with the lowest melting point is:
A、C18:0
B、C16:0
C、C14:0
D、C16:1cis-Δ9
E、C16:1trans-Δ9
7、The connection between the hydrophobic tail and the glycerol skeleton in the archaea phospholipid molecule is:
A、Ester bond
B、Amide bond
C、Ether bond
D、Glycosidic bond
E、Trans double bond
8、Trans fats are made from natural fats, and the reaction involved is:
A、oxygenation
B、hydration
C、hydrogenation
D、dehydrogenation
E、Saponification
9、The main force to maintain the stability of the lipid bilayer is:
A、hydrogen bond
B、ionic bond
C、hydrophobic interaction
D、Van der Waals forces
E、covalent bond
10、The intrinsic protein binding to the membrane is mainly through:
A、hydrogen bond
B、hydrophobic interaction
C、ionic bond
D、Van der Waals forces
E、covalent bond
11、The non-reducing carbohydrates include:
A、maltose
B、sucrose
C、arabinose
D、starch
E、glucose
12、The polysaccharides include:
A、starch
B、glycogen
C、cellulose
D、chitin
E、sucrose
13、The properties of polysaccharides include:
A、reducing
B、sweet
C、chiral
D、hydrolysis
E、a fixed molecular weight
14、Among the amphoteric lipids are:
A、fats
B、phospholipids
C、glycolipids
D、cholesterol
E、cholesterol ester
15、For animals, the essential fatty acids include:
A、Oleic acid
B、Linoleic acid
C、Arachidonic acid
D、alpha-linolenic acid
E、gamma-linolenic acid
16、The correct statements about fats include:
A、No fat on the membrane
B、Fat tends to pile up inside the cell, mainly stabilized by hydrophobic bonds
C、As an energy storage substance, its energy storage efficiency is higher than glycogen or protein
D、It is suitable as a long-term energy reserve for organisms
E、Fat also has the function of keeping warm and increasing buoyancy
17、The physiological functions of cholesterol include:
A、Precursor for Vitamin D
B、Raw material for steroid hormone synthesis
C、Raw material for bile acid synthesis
D、Components of animal cell membranes
E、Components of mycoplasma cell membrane
18、The biological macromolecules that can be used as animal energy reserves include:
A、choleserol
B、nucleic acids
C、glycogen
D、fats
E、proteins
19、All phospholipid molecules contain nitrogen atoms
20、The body can synthesize cholesterol by itself
21、All monosaccharides are reducing, and all polysaccharides are not reducing
22、The chiral sugars in nature are generally D-type, which is the opposite of amino acids.
23、Essential fatty acids are always unsaturated fatty acids
24、The double bond configuration in unsaturated fatty acids in nature is generally trans, because trans is more stable.
25、Natural fat is generally cis, its melting point is higher than trans fat
26、A glycogen molecule has only one reducing end, but has multiple non-reducing ends.
27、Amylase can hydrolyze both starch and glycogen
28、The blood sugar of insects and humans is glucose
Chapter 6 Structure and Function of Hormones
Quiz6
1、During the 24-hour fasting, liver glycogen is quickly depleted, while muscle glycogen storage is basically maintained. The reason for this difference is:
A、Myocytes lack glucagon receptors
B、Myocytes lack adenylate cyclase
C、Muscle glycogen phosphorylase is not affected by phosphorylation
D、Muscle cells lack receptors
E、Muscle cells lack insulin receptors
2、The metal ions that can act as hormone "second messengers" are:
A、Magnesium ions
B、Calcium ions
C、Sodium ions
D、Potassium ions
E、Zinc ions
3、The second messenger produced by acting on fat cells is:
A、cAMP
B、cGMP
C、IP3
D、DAG
E、Calcium ions
4、The enzymatic activity of all G proteins is:
A、ATPase
B、GTPase
C、CTPase
D、UTPase
E、Protein kinase
5、After the microinjection of EGTA into specific target cells, the hormone predicted to be affected is:
A、glucagon
B、insulin
C、GnRH
D、ANF
E、Thyroxine
6、The target molecule directly activated by NO in the cell is:
A、Adenylate cyclase
B、Guanylate cyclase
C、PKA
D、PKC
E、PKG
7、Clenbuterol can lose weight because it is a kind of:
A、uncoupler
B、Adrenaline agonist
C、Adrenaline antagonist
D、Activator of lipase
E、cAMP analogue
8、The enzymatic activity of the insulin receptor is
A、RTK
B、PKA
C、GTPase
D、Adenylate cyclase
E、Guanylate cyclase
9、Hormone that does not require G protein to function is:
A、Adrenaline
B、Glucagon
C、ACTH
D、ANF
E、GnRH
10、The fat-soluble hormones include:
A、Adrenaline
B、Thyroxine
C、Insulin
D、Sex hormone
E、Ethylene
11、Signal molecules that cannot be quantified by radioimmunoassay are:
A、ethylene
B、insulin
C、NO
D、glucagon
E、ANF
12、Hormones whose receptors have enzymatic activity include
A、insulin
B、NGF
C、ANF
D、EGF
E、glucagon
13、Suppose you have been cultivating a special cell line for a month to study the structure and function of the receptor, but a technician in your laboratory accidentally treated the cells you are cultivating with trypsin. Which hormones you are studying will be affected by his negligence?
A、insulin
B、glucagon
C、epinephrine
D、aldosterone
E、androgen
14、The correct statements about hormone receptors include:
A、All hormones require receptors
B、All hormone receptors are proteins
C、All water soluble hormone receptors are located in the cell membrane
D、All fat-soluble hormone receptors are in the cell
E、Hormones and receptors are generally bound by non-covalent bonds
15、Ser/Thr protein kinases include:
A、PKA
B、PKC
C、PKG
D、RTK
E、MEK
16、Which of the following statements about cAMP are correct?
A、The intracellular cAMP is catalyzed by adenylate cyclase
B、It can work in bacterial cells
C、It always works by activating PKA in the cell
D、Under the catalysis of A-PDE, it can be hydrolyzed to 3′-AMP
E、It is difficult to pass through the cell membrane by free diffusion
17、The components required for both visual and olfactory production include:
A、GPCR
B、G protein
C、GTP
D、ion channels
E、nucleotide cyclase
18、The G proteins include:
A、transducin
B、Ras
C、Ran
D、Raf
E、Rab
19、The components required for action of both insulin and glucagon include
A、G protein
B、GTP
C、ATP
D、protein kinase
E、Magnesium ions
20、All hormone receptors are proteins
21、All hormones require receptors to act on specific cells
22、Intracellular receptors for fat-soluble hormones are essentially transcription factors
23、Fat cells can also secrete hormones
24、Adrenergic receptors are essentially guanylate exchange factors
25、The second messenger always works through protein kinases
26、The receptors for EGF, NGF, IGF and PDGF are essentially enzymes.
27、G protein is required for the action of both insulin and glucagon
28、The immediate precursor of thyroxine is a protein
学习通是一款非常优秀的在线学习平台，其中最受欢迎的课程之一就是 Structural Biochemistry。
什么是 Structural Biochemistry？
Structural Biochemistry 又称为生物化学结构，是研究生物分子的三维结构及其与生命活动的关系的学科。它是生物化学、生物物理学和生物信息学的交叉学科，是生命科学中非常重要的一门学科。
Structural Biochemistry 的研究内容包括蛋白质、核酸、酶、生物膜等生物分子的结构、功能和相互作用等，其中以蛋白质结构研究最为广泛。
为什么要学习 Structural Biochemistry？
学习 Structural Biochemistry 对于生命科学领域的研究非常重要，具有以下几个方面的意义：
- 帮助我们更好地理解生物分子的结构、功能和相互作用，从而有助于我们进一步深入研究生命科学领域的各种问题。
- 为药物研发、生物工程、生物技术等应用领域提供基础支撑。
- 有助于提高生命科学领域的研究水平，从而为推动生物技术的发展做出贡献。
Structural Biochemistry 的学习方法
学习 Structural Biochemistry 需要掌握一些基本的学习方法，以下是一些建议：
- 注重基础知识的掌握：Structural Biochemistry 是一门交叉学科，需要掌握生物化学、生物物理学、生物信息学等多个学科的基础知识。
- 多看、多听、多实践：通过阅读教材、听课、实践等多种途径，加深对 Structural Biochemistry 的理解和掌握。
- 着重掌握蛋白质结构研究：蛋白质结构研究是 Structural Biochemistry 中最为重要的部分，需要着重掌握。
- 学会利用工具：Structural Biochemistry 的研究需要利用一些生物信息学工具，如分子模拟软件、蛋白质结构分析软件等。
Structural Biochemistry 的学习内容
Structural Biochemistry 的学习内容很丰富，以下是一些常见的内容：
- 生物分子的基本结构及其相互作用
- 蛋白质的一级结构、二级结构、三级结构和四级结构
- 蛋白质的折叠和稳定性
- 蛋白质的结构与功能关系
- 蛋白质结构的测定和分析方法
- 生物膜的结构和功能
- 酶的结构和催化机制
- 核酸的结构和功能
Structural Biochemistry 的应用领域
Structural Biochemistry 的研究可以应用到各个生命科学领域，以下是一些常见的应用领域：
- 药物研发：通过研究蛋白质的结构和功能，可以寻找到新的靶点，从而为药物研发提供新的思路和技术支持。
- 生物工程：蛋白质结构研究可以为生物工程中的蛋白质工程提供基础理论和实验支持。
- 生物技术：蛋白质结构研究可以应用于生物技术领域，如基因工程、蛋白质工程、生物制药等。
总结
Structural Biochemistry 是一门非常重要的生命科学交叉学科，通过学习 Structural Biochemistry 可以深入了解生物分子的结构、功能和相互作用，为药物研发、生物工程、生物技术等应用领域提供基础支撑。
事物的发展是一个过程。这个过程：
A.下列不属于民族说唱的种类是（）
B.腕横纹上3寸，掌长肌腱与桡侧腕屈肌腱之间的穴位是
C.防卫空间理论属于被害性理论。
D.《素问 六节藏象论》所论的五脏的'其充'中,肺其充在( )
当讲到“碗口一样粗的蟒蛇”时，导游员用手指比划了一下，这种手势称为（ ）。
A.分区策略可按以下（）进行分区
B.在/tmp目录下创建新目录lianxi2
C.关于调味四君子错误的是（）
D.兴奋通过神经-骨骼肌接头时，乙酰胆碱与受体结合使终板膜
与细绒棉相比，长绒棉长度长、细度细，适合纺制低线密度纱。
A.以下交易具有商业实质的是（ ）。
B.《金岳霖先生》的情节波澜起伏，富于悬念。
C.苯的硝化反应所用的试剂是（ ）
D.对某物质临界点的描述，不正确的是。
下列不属于霍兰德划分的六大类型的关系（）
A.如果出口日用消费品、轻工业品及机械产品常用的计量单位为（ ）
B.不属于一般杂质检查项目的是：
C.关于《二泉映月》，以下描述正确的有哪些
D.《狮身人面像》，坐落在埃及开罗西南，为（ ）金字塔的附属建筑。
人体的身高也是决定跳跃项目成绩的一个重要因素。
A.兼具分节和鳃裂构造双重属性的动物是（ ）。
B.影响消费者购买力水平和消费结构的重要因素是个人可自由支配收入。
C.受体阻断药(拮抗药)的特点是
D.电路如图所示，判断该电路为何种滤波电路
“保卫黄河”是钢琴协奏曲《黄河》的第几乐章
A.在细胞分裂中期，连接二姐妹染色单体的着丝粒进行横裂，将形成
B.变压器型冷却方式ONAN 表示该变压器铁芯的冷却介质是（ ）。
C.本量利分析的基本假设包括（ ）。
D.The sea is ____ calm.大海变得平静起来。
下列哪项不是介水传染病的流行特点有
A.导致蛔虫病广泛流行的因素很多，但除外：
B.上皮组织由排列紧密的上皮细胞和极少量细胞外基质组成
C.蒙古族服饰文化史是一部北方民族的发展史，下列属于北方游牧民族的有（ ）。
D.在ARM内存管理中，通常页的大小为（）
典型的证券违法行为包括()。
A.以下文件类型中，______是音频文件格式。
B.以下关于无穷小的描述中正确的有
C.木材给人的触觉体验有别于金属和塑料
D.言语可以增进和表明与他人的一致性。
商品流通企业管理费用不多的。
A.QR和ECR之所以不同是因为（）
B.含有电容和电感的电路不适用欧姆定理。
C.一旦企业将应收账款作为坏账处理后，就放弃了该项应收账款的索取权。（ ）
D.下列项目对内含报酬率计算没有影响的是
这个负反馈放大电路的组态是（）
A.下述哪项不是急性肾功能衰竭的发病环节
B.白色和银色是现代建筑的常用色调。
C.由琥珀酸脱下的一对氢，经呼吸链氧化可产生：（ ）
D.偶发事件的处理，重在解决某个具体的矛盾，教育某个具体的学生。
属人法系属公式主要解决（ ）方面的法律冲突。
A.勤学苦练，不断进取是会计人员遵守( )职业道德的基本要求。
B.TTL电路在正逻辑系统中，以下各种输入中______相当于输入逻辑“0”。
C.室内空气污染物，按其存在状态可分为气态污染物和颗粒污染物；按理化性质可分为
D.关于知情同意原则理解错误的是（）
关于单层扁平上皮的描述哪项错误
A.边角料和副产品以海关审查的外销价格为完税价格。()
B.本例题讲解中用了哪些方法（ ）
C.以下哪些税种体现了利益说的特征（ ）。
D.恢复古希腊罗马艺术的崇高荣誉是文艺复兴的重要内容之一。（）_
凡画林木，远者应如何处理，近者如何处理
A.自密实混凝土优点是只需要少量振捣。
B.《汉书》体例全部承袭了《史记》，但将《史记》中的哪一部分与列传合并
C.对目标分子进行拆开时，不能重复进行切断。
D.可逆变换把平行四边形变成矩形
炮采工艺运煤方式为刮板输送机运输
A.Hamlet is a revenge tragedy
B.料场在雨季使用立面开采法时,影响因素较小
C.图层对象的粗细可以通过（ ）来设置
D.为了改善放大电路的性能，电路中可适当引入正反馈。
